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Comparative Study of Wound Healing Activity of Topical and Oral Ocimum Sanctum Linn in Albino Rats

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Author(s): B. Asha | A. Nagabhushan | G.H. Shashikala

Journal: Al Ameen Journal of Medical Sciences
ISSN 0974-1143

Volume: 04;
Issue: 04;
Start page: 309;
Date: 2011;
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Keywords: Ocimum sanctum | Wound healing activity | topical | oral

ABSTRACT
Introduction: Ocimum sanctum, when given orally in one of the studies showed wound healing property. Since majority of the agents tried for wound healing are topical, the present study was planned to compare the oral and topical Ocimum sanctum for wound healing property. Methods: Excision and incision resutured wound models in albino rats were used to study complete epithelisation time, wound contraction, histopathological study and tensile strength of the wounds. Results: The animals were divided into four groups of oral test, control and topical test, control with 6 animals in each group. The time taken for 50% wound contraction and complete eipthelisation by oral Ocimum sanctum, topical Ocimum sanctum was significantly (p

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