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Comparing three adjuvant chemotherapy regimes after modified radical mastectomy in breast cancer patients using log-logistic model

Author(s): Javad Faradmal | Anoshirvan Kazemnejad | Reza Khoda Bakhshi | Ebrahim Hajizadeh | Mahmood Reza Gohari

Journal: Koomesh
ISSN 1608-7046

Volume: 11;
Issue: 04;
Start page: 279;
Date: 2010;
Original page

Keywords: Breast cancer | Adjuvant chemotherapy | Disease-free time | Survival analysis | Log-logistic model

Introduction: Chemotherapy after surgery is one of the adjuvant therapy components in breast cancerpatients. In the current study, Taxane-based and Anthracycline-based regimes were compared toCyclophosphamide, Methotrexate and 5-Fluorouracil (CMF) chemotherapy after modified radicalmastectomy (MRM) surgery in terms of disease-free survival (DFS).Materials and Methods: Sixty-two patients with confirmed breast cancer that underwent MRMsurgery at no metastasis stage (M0) enrolled. These patients were received one of the three types ofadjuvant chemotherapies that mentioned above and the relapse/metastasis in 8-year follow-up wasrecorded. In addition, some paraclinical and demographical factors were recorded and the efficacy of thedifferent chemotherapy regimes was compared using log-logistic survival model.Results: The mean age (SD) of patients was 49 (1.31). More than 40% of patients had tumors withgrade 3. The median time of follow-up was 20.0 months and the rate of 5-year DFS was 48%. Survivalanalysis indicated that type of chemotherapy (OR(Taxane/CMF) =3.676; OR (Anthracycline/CMF) =3.185),histological grade (OR=2.528), tumor size (OR=5.598) and number of lymph nodes (OR=1.112) affectthe DFS.Conclusion: The results of the current study indicated that the efficacy of Taxane-based andAnthracycline-based is more than CMF. This study also showed that early detection of tumor was animportant factor for a successful treatment in terms of DFS, and so, it declares the roll of screening andpublic education.
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