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The comparison of antibody titers secondary to intramuscularly, subcutaneous or intradermal application of low dose Hepatitis B vaccine

Author(s): Sabit Şahin | Yaşar Durmaz | Cengiz Yakıncı

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 2;
Issue: 3;
Start page: 277;
Date: 2011;
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Keywords: Hepatitis B | low dose vaccine | antibody titer | intramuscularly | subcutaneous | intradermal

Objectives: There are approximately 300 million HBV carriers where 25-30% of them had deceased due to cirrhosis or PHK. Universal vaccination is suggested worldwide against HBV because it is proven that vaccinating only the risk group is useless to reduce or eradicate the HB. However, the high costs limit its extensive usage. One way to reduce high costs is vaccinating in low dose. The purpose of this study is to determine the dependable, effective and low-cost dose as the result of evaluating the antibody titers against recombinant HB vaccine in three routes.Materials and methods: Antibody titers against three times intramuscularly (IM), subcutaneous (SC) and intradermal (ID) in different doses like 4μg, 10μg or 20μg were detected.Results: Totally, 96 newborn were chosen from HBsAg negative mothers and greater than 2500 gram in birth weight. They were randomly distributed into 7 groups. The recombinant HB vaccine (20 μg/0.5 ml. Gen-Hevac B. Pasteur Merieux) is applied as IM 20 μg (IM20) to 15, IM 10 μg (IM10) to 18, IM4μg (IM4) to 12, SC 20 μg to 12, SC 10 μg to 14, SC 4 μg to 10 and finally IM 4 μg to 15 babies after birth, at first month and sixth month. Six month after the third dose, the protective antibody titers gathered from the first four groups (100%, 93.4%, 91.6%, and 88.9% respectively) are accepted as sufficient.Conclusion: The application of low dose (4 pg) Hepatitis-B Vaccine via intradermal resulted in desired immunization level without reducing immune response and by reducing the cost five times. J Clin Exp Invest 2011; 2 (3): 277-281.
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