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Comparison Between the Effects of the Alcholic Extract of Mellissia Officinalis and Atorvastatin on Serum Levels of Thyroid Hormones in Hypercholesterolemic Male Rats

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Author(s): Ali Zarei | Saeed Changizi Ashtiyani | Mansour Sokhandani | Azam Rezaei | Saeed Zaheiri | Soheila Taheri

Journal: Zahedan Journal of Research in Medical Sciences
ISSN 2228-6403

Volume: 15;
Issue: 8;
Start page: 6;
Date: 2013;
Original page

Keywords: Atorvastatin | Hypercholesterolemia | Mellissia officinalis | Thyroid

ABSTRACT
Background: Consumption of unsaturated fats reduces the serum level of lipids and leptin. Thyroid hormones and leptin play pivotal roles in metabolism and their amounts are inter-related. This study was done to compare the effects of Mellissia officinalis extract and atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats.Materials and Methods: Consumption of unsaturated fats reduces the serum level of lipids and leptin. Thyroid hormones and leptin play pivotal roles in metabolism and their amounts are inter-related. This study was done to compare the effects of Mellissia officinalis extract and atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats.Results: The results showed that in experimental groups receiving the plant extract and atorvastatin, the concentration of thyroid hormones increased, whereas the amount of the thyroid-stimulating hormone showed a significant decrease (p

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