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Comparison of Bilirubin Level Changes in Schizophrenia and Type I Bipolar Disorder

Author(s): Yousef Semnani | Farzad Nazemi | Mohammad Javad Ehsani Ardakani | Aileen Azari Yam

Journal: Iranian Journal of Psychiatry and Clinical Psychology
ISSN 1735-4315

Volume: 15;
Issue: 2;
Start page: 208;
Date: 2009;
Original page

Keywords: schizophrenia; psychosis; bipolar disorder; bilirubin; Gilbert's disease

AbstractObjectives: The aim of this study was to evaluate bilirubin level changes in patients with schizophrenia and other psychotic disorders. Method: This was a comparative cross-sectional study. Hospitalized patients of at least 20 years of age, with the primary diagnosis of psychosis, were first evaluated using Structured Clinical Interview DSM-IV for Axis I disorders (SCID-I) and 162 patients with schizophrenia and 155 patients with bipolar mood disorders entered the study. Ninety five cardiac patients who were admitted to CCU with no personal and family history of psychosis were selected as the control group. Plasma levels of total and direct bilirubin, lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and prothrombin time (PT) as well as the reticulocyte count were measured for all of the subjects. Also, bilirubin levels at admission and at discharge were compared. Results: Distribution of age, sex and also positive and general psychopathology subscales were not significantly different in the relevant groups. Initial total bilirubin levels were higher in patients with schizophrenia (p
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