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A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injury

Author(s): Funk Duane | Graham M Ruth | Girling Linda | Thliveris James | McManus Bruce | Walker Elizabeth | Rector Edward | Hillier Craig | Scott J Elliott | Mutch W Alan

Journal: Respiratory Research
ISSN 1465-9921

Volume: 5;
Issue: 1;
Start page: 22;
Date: 2004;
Original page

Abstract Background Biologically variable ventilation (return of physiological variability in rate and tidal volume using a computer-controller) was compared to control mode ventilation with and without a recruitment manoeuvre – 40 cm H2O for 40 sec performed hourly; in a porcine oleic acid acute lung injury model. Methods We compared gas exchange, respiratory mechanics, and measured bronchoalveolar fluid for inflammatory cytokines, cell counts and surfactant function. Lung injury was scored by light microscopy. Pigs received mechanical ventilation (FIO2 = 0.3; PEEP 5 cm H2O) in control mode until PaO2 decreased to 60 mm Hg with oleic acid infusion (PaO2/FIO2
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