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A Comparison of the Effects of Typical and Atypical Antipsychotics on Inducing Obsessive-Compulsive Symptoms in Patients with Schizophrenia

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Author(s): Shima Mohseni | Azizeh Afkham Ebrahimi | Badry Daneshamouz

Journal: Iranian Journal of Psychiatry and Clinical Psychology
ISSN 1735-4315

Volume: 13;
Issue: 4;
Start page: 328;
Date: 2008;
Original page

Keywords: typical antipsychotics | atypical antipsychotics | obsessive-compulsive symptoms | schizophrenia

ABSTRACT
AbstractObjectives: The effects of typical and atypical antipsychotics on inducing obsessive-compulsive symptoms in patients with schizophrenia were compared in this study. Method: In a comparative-descriptive study 64 patients with schizophrenia (32 patients in typical antipsychotic group and 32 patients in atypical antipsychotic group) were investigated. All patients with a confirmed diagnosis of schizophrenia based on Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), underwent Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Brief Psychiatric Rating Scale (BPRS) at the beginning, as well as three and six weeks after treatment. Data were analyzed using descriptive statistics, repeated measures analysis of variance, and t-test. Results: In the group receiving typical antipsychotics, mean Y-BOCS scores were 2.40, 2.30, and 2.18 at the beginning, at three weeks and at six weeks after treatment respectively. Also, in the group receiving atypical antipsychotics Y-BOCS scores were 4.12, 4.46, and 4.53 at the beginning, at three weeks and at six weeks after treatment respectively. The difference of Y-BOCS scores in the two groups receiving typical and atypical antipsychotics was close to significance before treatment, and significant at three and six weeks after treatment (p

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