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Comparison of the efficacy of dexmedetomidine and esmolol in the treatment of increased hemodynamic response during the recovery period

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Author(s): Hülya Günay | Elif Başağan Moğol | Fatma Nur Kaya | Gürkan Türker | Belgin Yavaşcaoğlu | Filiz Ahun | Ayşe Neslihan Bebek | Tuba Yeniaydoğmuş

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 3;
Issue: 1;
Start page: 53;
Date: 2012;
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Keywords: Dexmedetomidine | esmolol | extubation | hemodynamic response | cognitive function

ABSTRACT
Objectives: Our aim was to compare effectiveness of esmololand dexmedetomidine in the treatment of increasedhemodynamic response during anesthesia recovery period.Materials and methods: 60 ASA I-II patients whomscheduled for elective surgery with endotracheal intubationwere randomized before extubation according to theirhemodynamic parameters that were increased 20% oftheir baseline values in order to receive 1mg/kg esmolol(Group Esmolol, n= 30) or 0.5 μg/kg dexmedetomidine(Group Dexmedetomidine, n= 30). Heart rate (HR), systolicand diastolic blood pressures (SBP,DBP), peripheral oxygensaturation (SpO2), end tidal carbon dioxide (ETCO2)values, extubation time, recovery time were recorded. Theduration till having pain requiring analgesic was recordedand cognitive functions were evaluated with short memoryorientation concentration test at 20th and 50th minutes.Results: After drug, HR reductions were significant at allperiods in group Dexmedetomidine (Z2-Z10: p
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