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Comparison of efficiency and toxicity of two chemotherapy protocols in treatment of advanced non-small cell lung cancer

Author(s): Mekić-Abazović Alma | Šišić Ibrahim | Kovčin Vladimir | Bečulić Hakija | Dervišević Senad | Musić Miralem

Journal: Medicinski Pregled
ISSN 0025-8105

Volume: 64;
Issue: 7-8;
Start page: 368;
Date: 2011;
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Keywords: Carcinoma | Non-Small-Cell Lung | Antineoplastic Combined Chemotherapy Protocols | Antineoplastic Combined Chemotherapy Protocols + toxicity | Treatment Outcome | Cisplatin | Etoposide | Vinblastine + analogs and derivatives | Lung Neoplasms + drug therapy

Introduction. This study was aimed at comparing the efficiency and tolerability of two reference protocols Cisplatin and Etoposide and Cisplatin and Vinorelbine in advanced Non-Small Cell Lung Cancer. Material and Methods. A total of 60 patients (two groups consisting of 30 patients) were treated for advanced Non-Small Cell Lung Cancer during the period from January to December 2005 according to the reference protocols (Cisplatin 100mg/m2 D1; Vinorelbine 30 mg/m2 D1, D8 on 4 weeks) and (Cisplatin 100 mg/m2 D1; Etoposide 100 mg/m2 D1, D3, D5 on 4 weeks) at the Department of Oncology of KBC ”Bežanijska kosa”. All patients were analyzed for tumour response, progression free survival as well as for toxicity. X2 test, Kaplan Meiers curves and Log rank test were used for statistical analysis. Results. Although the recorded response rates were a bit lower than in previously published trials, they were not significantly different p=0.485. No statistically significant difference was recorded in either progression free survival or overall survival. The chemotherapeutical Cisplatin/Etoposide protocol proved to be more toxic both in hematologic (3% vs. 10%) and total toxicities (p=0.047). Conclusion. Our study proved both protocols to have equivalent efficacy. However, the Cisplatin, Vinorelbine protocol could be recommended because of its less expressed toxic effects.
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