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Comparison the inflammatory effects of early supplemental parenteral nutrition plus enteral nutrition versus enteral nutrition alone in critically ill patients

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Author(s): R Abrishami | A Ahmadi | M Abdollahi | A Moosivand | H Khalili | A Najafi | K Gholami | H Hamishehkar | A Peivandi Yazdi | M Mojtahedzadeh

Journal: DARU : Journal of Pharmaceutical Sciences
ISSN 1560-8115

Volume: 18;
Issue: 2;
Start page: 103;
Date: 2010;
Original page

Keywords: Enteral nutrition | Parenteral nutrition | Inflammation

ABSTRACT
"n  "n Background and the purpose of the study:It is believed that enteral nutrition (EN) support is the preferred route as compared to parenteral nutrition (PN). Critically ill patients on EN receive less than 60% of their metabolic requirements. To meet patients' calorie goal addition of PN to EN was proposed. This study was conducted to determine whether supplemental PN have any difference with EN alone in regard to inflammatory indices. "n "nMethods:Twenty patients were randomized to either receive EN alone or EN+PN for 7 days. Pre albumin and inflammatory indices including interleukin IL-1, IL-6 and tumor necrosis factor-α (TNF-α) were measured on days of 0, 3,7. Also Sequential Organ Failure Assessment (SOFA) score and Therapeutic Intervention Scoring System-28 (TISS-28) score were calculated on days of 0, 3 and 7. "nResults and major conclusion:IL-1, IL-6 and TNF-α did not show significant difference between two interventions. Pre-albumin was increased from baseline by 9% and 81% in EN and EN+PN groups respectively but it did not reach to statistical significance. SOFA score did not show significant difference. TISS score was higher in EN+PN group on days of 3 and 7. "nNo difference was found between EN and EN+PN regimens in regard to inflammation, while severity of illness may not change with these regimens, nursing workload increases with implementation of supplemental PN.
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