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A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin

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Author(s): Teixeira Mauro M | Miotla JM | Cooper N | Gristwood RW | Hellewell PG

Journal: Memórias do Instituto Oswaldo Cruz
ISSN 0074-0276

Volume: 92;
Issue: suppl.2;
Start page: 193;
Date: 1997;
Original page

Keywords: eosinophils | phosphodiesterase inhibitors | rolipram | allergic inflammation

ABSTRACT
The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil migration in guinea pig skin. In the present study we compare the oral potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840 on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401 were equally effective and potent when given by the oral route and much more active than the PDE4 inhibitor CDP 840. We suggest that this guinea pig model of allergic and mediator-induced eosinophil recruitment is both a sensitive and simple tool to test the efficacy and potency of PDE4 inhibitors in vivo.
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