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Comparison of Saffron Stigma and Placebo in the Treatment of Metastatic Liver Disease

Author(s): Masoud Pezeshki Rad | Seyed Hadi Mousavi | Hamid Reza Raziee | Fatemeh Homaee Shandiz | Seyed Hamed Moosavi

Journal: Iranian Journal of Radiology
ISSN 1735-1065

Volume: 8;
Issue: S1;
Start page: 68;
Date: 2011;
Original page

Keywords: Liver | Metastasis | Computed Tomography | Saffron

Background/Objective: Cancer continues to"nrepresent the second cause of mortality in the world."nSaffron as a medicinal plant is known for anti-cancer"nand anti depressant properties. This is a pilot double"nblind study to evaluate effects of saffron stigma on"nresponse to treatment in patients suffering from liver"nmetastasis."nPatients and Methods: Twelve patients suffering"nfrom liver metastases were divided into two different"ngroups. Both groups received their chemotherapy"nregimen. Group 1 was also treated with saffron (50"nmg twice daily) during chemotherapy periods. Group"n2 received placebo during the study. The sum of the"nlongest diameter of all metastatic lesions before and"nafter treatment in contrast enhanced CT scans were"ncalculated and compared."nResults: Of the 12 patients included in the study, five"npatients were excluded and seven patients remained."nIn the saffron-treated group two patients had partial"nand complete response (50%); however, in the placebo"ngroup, there was no response. There were also two"nmortalities in the placebo and one mortality in the"nsaffron group. Major side effects were not seen in"nsaffron treated patients, only one mild reaction which"nwas removed with reduced dosage of saffron."nConclusion: Saffron stigma might be useful in patients"nsuffering from liver metastasis but this study needs to"nbe continued with more patients."nKeywords: Liver, Metastasis, Computed Tomography,"nSaffron

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