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Comparison of spinal vasculature in mouse and rat: investigations using MR angiography

Author(s): Bilgen M | Al-Hafez B

Journal: Neuroanatomy
ISSN 1303-1783

Volume: 5;
Issue: 1;
Start page: 12;
Date: 2006;
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Keywords: magnetic resonance imaging | angiography | inductively coupled surface coil | spine | spinal cord | spinal vasculature

The first goal of this work is to demonstrate the feasibility of performing three-dimensional, time-of-flight magnetic resonance angiography (MRA) on the spine and spinal cord (SC) of mouse. The MRA studies were performed at 9.4 T magnetic field strength using a custom designed inductively coupled surface coil. The results of the present study demonstrate the possibility of remotely imaging the arteries supplying blood to the mouse spine and spinal cord at high spatial resolution and high signal-to-noise ratio. Data also show that the arteries in the parenchyma of the SC are highly organized with projections at multiple levels along the cord, as originating from the anterior spinal artery. The second goal is to compare the arterial organization in mouse and rat at the spinal level and to explain cause-and-effect relationship to examine the differences observed in the neuropathologies following spinal cord injury in these species.

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