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Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model

Author(s): Ebru Eren Akar | Veysi Öner | Cem Küçükerdönmez | Yonca Aydın Akova

Journal: International Journal of Ophthalmology
ISSN 2222-3959

Volume: 6;
Issue: 2;
Start page: 136;
Date: 2013;
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Keywords: corneal neovascularization | bevacizumab | ranibizumab | pegaptanib | subconjunctival injection

AIM:To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model.METHODS:Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups:bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15th day.RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P
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