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Comparison of sublingual, vaginal, and oral misoprostol in cervical ripening for first trimester abortion

Author(s): Parveen Shagufta | Khateeb Zaffar | Mufti S | Shah M | Tandon Vishal | Hakak S | Singh Z | Yasmeen Shagufta | Mir Shakeel | Tabasum Rehana | Jan Nasreen

Journal: Indian Journal of Pharmacology
ISSN 0253-7613

Volume: 43;
Issue: 2;
Start page: 172;
Date: 2011;
Original page

Keywords: Cervical ripening | first trimester abortion | misoprostol | surgical evacuation

Objectives : To compare the effectiveness and tolerability of misoprostol as a cervical ripening agent in first trimester abortion through three different routes of administration before surgical evacuation (SE). Materials and Methods : It was a hospital based prospective randomized open labeled parallel study. A total of 150 randomly selected married women were divided in three groups for sublingual (S/L), vaginal and oral 400 μg of misoprostol single dose administration. The drug was administered 3-4 h before SE in the S/L and vaginal groups and 12 h before the procedure in the oral group. Efficacy was assessed on the basis of time taken for ripening, dilatation achieved, duration of the procedure, intra-operative blood loss, and pain score. The tolerability was noted on the basis of side effects. Results : The mean time taken for cervical ripening was less in sublingual administration (3.7±1.2 hr) as compared to the vaginal and oral routes. The S/L group had significant cervical dilatation (P
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