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Compatibility and stability studies of erythromycin Estolate and Piperine mixture

Author(s): Kunchithapatham. Janakiraman* and Rajappan Manavalan

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3405;
Date: 2011;
Original page

Keywords: Erythromycin | Piperine | Bioenhancer. Compatibility studies | Stability studies

Erythromycin and its derivatives are used to treat variety of Bacterial infections in Humans. Piperine, an alkaloid from Piper species is reported to enhance oralbioavailability of co-administered drugs. The present study was aimed to include to Piperine (bioenhancer) as a formulation additive in oral formulations ofErythromycin estolate. So, a Physical mixture of Erythromycin estolate and Piperine (1:1) was tested for their compatibility by DSC, TLC and FT-IRtechniques. Stability of the mixture was assessed by the use of ICH guidelines. The above studies have proved that Piperine can be used as a formulation additive(bioenhancer), in oral formulations of Erythromycin estolate.
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