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Compensatory Growth Induced in Zebrafish Larvae after Pre-Exposure to a Microcystis aeruginosa Natural Bloom Extract Containing Microcystins

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Author(s): Issam El Ghazali | Sanaa Saqrane | Antonio Paulo Carvalho | Youness Ouahid | Brahim Oudra | Francisca Fernandez Del Campo | Vitor Vasconcelos

Journal: International Journal of Molecular Sciences
ISSN 1422-0067

Volume: 10;
Issue: 1;
Start page: 133;
Date: 2009;
Original page

Keywords: Cyanobacterial bloom extract | Natural risk | Microcystins | Malformations | Compensatory growth

ABSTRACT
Early life stage tests with zebrafish (Danio rerio) were used to detect toxic effects of compounds from a Microcystis aeruginosa natural bloom extracton their embryolarval development. We carried out the exposure of developing stages of fish to complex cyanobacterial blooms containing hepatotoxic molecules - microcystins. Fish embryo tests performed with the bloom extract containing 3 mg·L-1 Eq microcystin-LR showed that after 24 h of exposure all fish embryos died. The same tests performed with other diluted extracts (containing 0.3, 0.1 and 0.03 mg·L-1 Eq microcystin-LR) were shown to have an influence on zebrafish development and a large number of embryos showed malformation signs (edema, bent and curving tail). After hatching the larvae were transferred to a medium without toxins to follow the larval development under the new conditions. The specific growth of the pre-exposed larvae was significantly more important than that of the control larvae. This may represent a compensatory growth used to reduce the difference in size with the control fish noted after hatching.
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