Academic Journals Database
Disseminating quality controlled scientific knowledge

Complexity of diabetic nephropathy pathogenesis and design of investigations

ADD TO MY LIST
 
Author(s): Tavafi Majid

Journal: Journal of Renal Injury Prevention
ISSN 2345-2781

Volume: 2;
Issue: 2;
Start page: 59;
Date: 2013;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Diabetic nephropathy | Pathogenesis | Treatment | Mediators

ABSTRACT
Diabetic nephropathy (DN) pathogenesis is very complex and multifactorial. There are several mechanisms or pathways that hyperglycemia leads to renal injuries. Each pathway makes renal injuries via several mediators. Some mediators are common between the pathways such as reactive oxygen species (ROS) and TGF-β and there are many overlaps and interference between the pathways. This review summarized complexity of DN pathogenesis and overlaps or interfering of mediators between the pathogenesis pathways. Besides, in the review suggested new designs of researches based on this complexity pathogenesis. The pathogenesis of DN is certainly very complex and multifactorial. From the overview of molecular mechanisms of DN pathogenesis, there are many pathways and many mediators with many interferences and overlaps between them. The focal point of this pathogenesis still unknown but it seems that RAAS system, oxidative stress and TGF-β relatively are common between these complex tangle webs of pathogenesis.
Affiliate Program      Why do you need a reservation system?