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Composition and Bioactivity of the Essential Oil of Anethum graveolens L. from Tajikistan

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Author(s): Farukh S. SHAROPOV | Michael WINK | Isomiddin S. GULMURODOV | Salomiddin J. ISUPOV | Hanjing ZHANG | William N. SETZER

Journal: International Journal of Medicinal and Aromatic Plants
ISSN 2249-4340

Volume: 3;
Issue: 2;
Start page: 125;
Date: 2013;
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Keywords: Dill | essential oil composition | carvone | cytotoxicity

ABSTRACT
The essential oil of Anethum graveolens L. was obtained from the aerial parts by hydrodistillation. Its composition was analyzed by high-resolution gas chromatography – mass spectrometry (GC-MS). Thirteen components were identified representing 99.6% of the total oil composition. The major components were carvone (51.7%), trans-dihydrocarvone (14.7%), dill ether (13.2%), α-phellandrene (8.1%) and limonene (6.9%). The cytotoxicity of the oil was tested against HeLa, Caco-2 and MCF-7 cancer cell lines: IC50 values were 93 μg/mL for HeLa, 216 μg/mL for Caco-2, and 67 μg/mL for MCF-7 cell lines. Anethum graveolens essential oil was active in the brine shrimp lethality test (LC50 = 15.9 ± 2.3 μg/mL), but showed only marginal antimicrobial activity against Escherichia coli (MIC = 625 μg/mL). In addition, the ethnopharmacological uses of Anethum graveolens from difference geographical locations have been summarized.
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