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Computational Modeling of Cell Survival Using VHDL

Author(s): Shruti Jain1, | Pradeep K. Naik | Sunil V. Bhooshan

Journal: BVICAM's International Journal of Information Technology
ISSN 0973-5658

Volume: 2;
Issue: 1;
Date: 2010;
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Keywords: Tumor necrosis factor-α | Epidermal growth factor | Insulin | AkT (PKB).

The model for cell survival has been implemented using VeryHigh Speed Integrated Circuit Hardware DescriptionLanguage (VHDL) (Xilinx Tool) taking three input signals:Tumor necrosis factor-α (TNF), Epidermal growth factor(EGF) and Insulin. Cell survival has been regulated by theinteraction of five proteins viz P13K, TNFR1, EGFR, IRS andIKK in a network. In the absence of any one, in protein networkleads to cell death. For the EGF input signal the proteins likeMEK, ERK, AkT, Rac & JNK have been important forregulation of cell survival. Similarly for TNF and Insulin inputsignal proteins like NFκB, AkT, XIAP, JNK, MAP3K & MK2and MEK, ERK, AkT, Rac, mTOR & JNK respectively havebeen important for regulation of cell survival.
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