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Computer augmented modeling studies of Cu2+, Ni2+ and Co2+ complexes of ethambutol

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Author(s): G. Nageswara Rao | M. Mathrusri Annapurna

Journal: Journal of Pharmaceutical Education and Research
ISSN 0976-8173

Volume: 1;
Issue: 1;
Start page: 44;
Date: 2010;
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Keywords: Ethambutol | protonation constants | stability constants | MINIQUAD75

ABSTRACT
The protonation and complexation equilibria of Ethambutol dihydrochloride have been studied pH-metrically in aqueous medium at an ionic strength of 0.1 mol dm-3 and 303K temperature. Its protonation constants as well as the binary stability constants of Cu2+, Ni2+ and Co2+complexes were evaluated and the best-fit models were chosenbased on the statistical parameters using MINIQUAD75 computer program. The species distribution diagrams of the binary metal complexes are reported.
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