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Conservative procedures in skin reconstitution

Author(s): Wollina, Uwe

Journal: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
ISSN 1865-1011

Volume: 4;
Start page: Doc17;
Date: 2005;
Original page

Keywords: stratum corneum barrier | lamellar bodies | antimicrobial peptides | irritant contact dermatitis | radiodermatitis | acne | atopic dermatitis | wound healing | moisturizer | dexpanthenol | calcineurin inhibitors | hyaluronic acid | growth factors | tissue engineering | wound bed preparation

Skin exerts a number of essential protective functions ensuring homeostasis of the whole body. In the present review barrier function of skin and its expression of antimicrobial peptides are discussed. Barrier function is provided by the dynamic stratum corneum structure composed of lipids and corneocytes. Stratum corneum is a conditio sine qua non for terrestrial life. Impairment of barrier function can be due to injury and inflammatory skin diseases. Therapeutic options are discussed with special emphasis of radiodermatitis and irritant contact dermatitis in patients with hearing device. The use of antimicrobial peptides is illustrated by facial inflammatory skin diseases. In wound healing new developments include biotechnological developments of matrix- and growth factors and tissue-engineered skin substitutes. In everyday wound care of chronic wounds the concept of wound bed preparation (TIME) constitutes the base of successful treatment.
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