Academic Journals Database
Disseminating quality controlled scientific knowledge

Contextual Multiple Sequence Alignment

ADD TO MY LIST
 
Author(s): Gambin Anna | Otto Rafał

Journal: Journal of Biomedicine and Biotechnology
ISSN 1110-7243

Volume: 2005;
Issue: 2;
Start page: 124;
Date: 2005;
Original page

ABSTRACT
In a recently proposed contextual alignment model, efficient algorithms exist for global and local pairwise alignment of protein sequences. Preliminary results obtained for biological data are very promising. Our main motivation was to adopt the idea of context dependency to the multiple-alignment setting. To this aim the relaxation of the model was developed (we call this new model averaged contextual alignment ) and a new family of amino acids substitution matrices are constructed. In this paper we present a contextual multiple-alignment algorithm and report the outcomes of experiments performed for the BAliBASE test set. The contextual approach turned out to give much better results for the set of sequences containing orphan genes.
Save time & money - Smart Internet Solutions      Why do you need a reservation system?