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Convenient synthesis of some new pyrazolo[5,1-c]triazines, isoxazolo[3,4-d] pyrimidine and pyridine derivatives containing benzofuran moiety

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Author(s): Abdou Osman Abdelhamid | Abdelgawad Ali Fahmi | Amna Ali Mohamed Alsheflo

Journal: European Journal of Chemistry
ISSN 2153-2249

Volume: 3;
Issue: 2;
Start page: 129;
Date: 2012;
Original page

Keywords: Triazines | Pyridines | Pyrazoles | Isoxazoles | Hydrazones | Benzoimidazo[2 | 1-c][1 | 2 | 4]triazine

ABSTRACT
Pyrazolo[5,1-c][1,2,4]triazine, [1,2,4]triazolo[3,4-c][1,2,4]triazine, benzo[4,5]-imidazo[2,1-c][1,2,4]triazine, isoxazole, isoxazolo[3,4-d]pyridazine, pyrazole, pyridine, substituted urea and phenyl carbamate derivatives containing benzofuran moiety were synthesized via reaction of sodium salt of 5-hydroxy-l-benzofuran-2-ylpropenone or 1-(benzofuran-2-yl)-3-(dimethylamino)prop-2-en-1-one with diazotized heterocyclic amines, hydroximoyl chlorides and active methylene compounds. The structures of all the newly synthesized compounds were confirmed by elemental analyses, spectral data, and alternative synthetic routes, whenever possible.
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