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Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand

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Author(s): Chaoyu Wang | Lijuan Liu | Wei Wang | Dong-Sheng Ma | Hua Zhang

Journal: Molecules
ISSN 1420-3049

Volume: 15;
Issue: 3;
Start page: 1154;
Date: 2010;
Original page

Keywords: copper | (S)-N-methylpyrrolidine-2-carboxylate | arylations | amides

ABSTRACT
(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.

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