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Correlation between cytology and histopathology of the salivary gland

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Author(s): Singh A | Haritwal A | Murali BM

Journal: Australasian Medical Journal
ISSN 1836-1935

Volume: 4;
Issue: 2;
Start page: 66;
Date: 2011;
Original page

Keywords: Salivary gland | Fine needle aspiration cytology | Histopathology | diagnostic accuracy.

ABSTRACT
BackgroundSalivary gland swellings can result from tumours, aninflammatory process, or cysts. It can sometimes be difficultto establish whether pathology arises from the salivarygland itself or adjacent structures. Fine needle aspirationcytology (FNAC) is a simple, rapid and safe method todiagnose salivary gland swelling. FNAC has high sensitivity,specificity and accuracy. The aims of this study are tocorrelate FNAC diagnoses with histopathology and toestablish the sensitivity and specificity of FNAC in diagnosisof salivary gland swellings in our institution.MethodThe study was conducted in the department of pathology,Sri Venkateshwara Medical college Hospital and researchCentre, Pondicherry, India. Data was collectedretrospectively for the time period 2007-2008 andprospectively for that obtained between January 2009 andJune 2010. Results of cytologicial assessment werecompared with histopathological data where possible toestablish sensitivity and specificity of FNAC.ResultsDuring the study period, 1309 FNAC were undertaken ofwhich 96 FNAC were of salivary gland swellings. Correlationof cytology from FNAC with histopathology tissue waspossible in 56 cases. Of the 96 cases for which FNAC datawas available, 38.56% were from male and 61.45% werefrom female patients. The age of the patients ranged from 8to 69 years. 48.95% cases were benign swellings, 13.54%were malignant, 6.25% were cysts and 31.25% had aninflammatory aetiology. Comparison of FNAC findings withhistopathology specimens was available for 56 (58.33%)cases, following which the sensitivity and specificity ofcytology were found to be 76.9% and 97.1% respectively.ConclusionFNAC is highly sensitive and specific technique for diagnosisof most of the salivary gland swelling. FNAC can be usedpreoperatively to avoid unnecessary surgery and discomfortassociated with open biopsy.
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