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Correlation of Hormone Receptors with Her-2 Neu Protein Expression and the Histological Grade in Invasive Breast Cancers in a Cohort of Saudi Arabia

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Author(s): Maha ARAFAH

Journal: Türk Patoloji Dergisi
ISSN 1018-5615

Volume: 28;
Issue: 1;
Start page: 38;
Date: 2012;
Original page

Keywords: Breast neoplasms | Her-2/neu | Hormone receptors

ABSTRACT
Objective: Data on Hormone Receptor and Her-2/neu expression in breast cancers from Saudi Arabia and Gulf Region is sparse. We undertook this study to describe the patterns of hormone receptor and Her-2/neu protein expression in breast carcinoma and compared them with the histological grade at a University Hospital in Riyadh.Material and Method: We conducted a retrospective study on 164 invasive ductal carcinoma of breast between the year 2002 and 2008. Immunohistochemical analysis for Estrogen and Progesterone Receptor and Her-2/neu was done in all the cases. Fluorescent in situ hybridization for Her-2/neu gene amplification was performed in all 2+ cases and few equivocal 1+ and 3+cases by immunohistochemistry. Correlation between Estrogen and Progesterone Receptor and Her-2/ neu amplification and grade of tumor was calculated.Results: The expression of Estrogen Receptor, Progesterone Receptor were significantly correlated (p
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