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Correlation of lipid profile and QT interval, T-wave changes as a risk factor for cardiovascular disease

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Author(s): G.V. Lathadevi | S. Anusha

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 03;
Issue: 02;
Start page: 20;
Date: 2012;
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Keywords: Abnormal lipid profile | Corrected QT interval | QT interval | T-wave changes

ABSTRACT
Cardiovascular disease (CVD) remains the leading cause of death and disability worldwide. Dyslipidemia is an important risk factor for the initiation and progression of atherosclerosis and is strongly associated with cardiovascular events. Many studies in the past have established the value of lipid profile abnormalities and the ECG changes- QT interval prolongation and T wave inversion as markers of future adverse cardiovascular events. This study will try to establish if these two individual risk factors are associated with each other or not. It was a prospective, observational study conducted on 40 subjects of abnormal lipid profile compared to 40 control subjects both of whom were otherwise healthy. In the ECG, parameters like RR interval and heart rate, QT interval (QTi), Corrected QT interval (QTC), T wave changes (inversion) was calculated and noted, then compared with both the groups. By the independent sample‘t’ test, when compared to the control group, the group with abnormal lipid profile showed a significant QTi prolongation (by P

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