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Cumulative cardio-vascular risk in hypertensive patients: effects of angiotensin converting enzyme inhibitors

Author(s): L.I. Katelnitskaya | L.A. Haisheva | S.E. Glova

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 3;
Issue: 5;
Start page: 9;
Date: 2007;
Original page

Keywords: arterial hypertension | sex | age | cardio-vascular risk | SCORE scale | PROCAM program | speed of pulse wave spread | enalapril

Aim. To assess cumulative cardio-vascular (CV) risk and elasticity of big-to-middle size arteries in hypertensive patients depending on age, sex and enalapril (Enap, Dr. Reddy’s)effects on these features.Material and methods. 143 patients with arterial hypertension of 1-2 stages were split in 3 groups: 1st – patients younger than 55 y.o. (17men, 27 women beforemenopause); 2nd – patients aged 55-65 y.o. (16 men, 38 women); 3rd – elder than 65 y.o. (11 men, 34 women). Fatal CV risk according to SCORE scale and cumulative risk of acute coronary disease (CAD) events according to PRCAM program was assessed before and after 4weeks of enalapril therapy (5-30mg/d). Besides the speed of pulsewave spread (SPWS) was determined by method of volume sphygmography.Results. Normal SPWS in elastic arterieswas observed inwomen under 55 y.o. SPWS disturbanceswere detected in elderly patients. Lower blood pressure (BP) levels and better plasma lipid profile was found in women of young and middle age in comparison with these in men of the same age.More than 80%of hypertensive patients have high CV risk, especially in elderly ones. Enam improved SPWS in elastic arteries, reduced BP and cumulative CV risk.Conclusion. There are gender and age differences between BP levels, SPWS indices, plasma lipid profiles and cumulative CV risks in hypertensive patients. Enalapril improves these characteristics.
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