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The current concept of development of specialized intercellular connections between cardiomyocytes

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Author(s): Petruk N.S. | Tverdokhleb I.V.

Journal: Морфологія
ISSN 1997-9665

Volume: 3;
Issue: 3;
Start page: 6;
Date: 2009;
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Keywords: intercellular communication | intercalated disk | ontogenesis

ABSTRACT
The understanding of development of interrelation between electric and mechanical contacts in ontogenetic aspect can throw light on the mechanisms underlying heart pathologies related with local disturbance of gap junctions distribution. Despite of significant progress in understanding of structural biology of desmosome, fascia adherents and gap junctions which are a part of an intercalated disk, the detailed characteristic of interrelation between electric and mechanical connections it is not presented still now in the literature. So, data about formation, becoming, development and regulation of specific pattern of intercellular connections remain fragmentary and do not allow to make complete representation about ontogenetic features of formation of communicative contacts between cardiomyocytes. Understanding of development of an intercalated disk young heart, are important for optimization of terms of surgical intervention in pediatrics in occasion of congenital heart diseases. On the other hand, changes of the organization of intercellular contacts, first of all gap junctions, can lead to abnormal conductivity and arrhythmogenesis. Knowledge of similar aspects of development arrhythmias can push to development of new therapeutic methods which will provide higher efficiency of treatment at, for example, ischemic illness of heart or intimate insufficiency.
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