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Current concepts on anti-Phospholipase A2 receptor antibody in Idiopathic membranous nephropathy

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Author(s): Ardalan Mohammad Reza

Journal: Journal of Renal Injury Prevention
ISSN 2345-2781

Volume: 2;
Issue: 2;
Start page: 71;
Date: 2013;
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Keywords: Membranous nephropathy | Nephrotic syndrome | Phospholipase A2 receptor | Anti-PLA2R antibody

ABSTRACT
Implication for health policy/practice/research/medical education:Phospholipase A2 receptor, is normally expressed in podocyte membrane. In fact the phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a number of biological responses produced by secretory phospholipase A2s (sPLA2s). Determining anti-PLA2r serum levels in patients with nephrotic syndrome should designate a probable diagnosis of idiopathic membranous nephropathy and in patients in which idiopathic membranous nephropathy had a pathology confirmation may be a determining factor to exclude secondary forms of the disease. However, it is too early to abandon a kidney biopsy in patients with nephritic syndrome, and PLA2R as the newly introduced serologic study needs confirmations to finds its proper place in the field of clinical medicine.
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