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Current perspectives in the treatment of resistant schizophrenia

Author(s): Solanki R | Singh Paramjeet | Munshi Deepti

Journal: Indian Journal of Psychiatry
ISSN 0019-5545

Volume: 51;
Issue: 4;
Start page: 254;
Date: 2009;
Original page

Keywords: Adjuvant therapy | clozapine | treatment resistance

This article summarizes the current knowledge base on the diagnosis and management of treatment resistant schizophrenia. While the prevalence of treatment resistant schizophrenia is definition dependent, estimates have ranged from 30% to up to 60%. This article first looks into the various diagnostic criteria of treatment resistant schizophrenia. Then the literature is reviewed about the pharmacotherapeutics of its management. Clozapine emerges to be the gold standard. In addition risperidone and high dose olanzapine also emerge as clinically useful options. Other emerging adjunctive treatment options are equally addressed.

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