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Current Status of Tablet Disintegrants:A Review

Author(s): Mr. Uddhav S. Bagul | Mr. Nilesh S. Bagul | Ms. Minal S. Kulkarni | Dr. S. D. Sawant | Dr. K. N. Gujar | Mr. A. A. Bidkar

Journal: Pharmaceutical Reviews
ISSN 1918-5561

Volume: 4;
Issue: 4;
Date: 2006;
Original page

Despite increasing interest in controlled-release drug delivery systems, the most common tablets are those intended to be swallowed whole and to disintegrate and release their medicaments rapidly in the gastrointestinal tract (GIT).The proper choice of disintegrant or superdisintegrant and its consistency of performance are of critical importance to the formulation development of such tablets.Drug release from a solid dosage form can be enhanced by addition of suitable disintegrants. In more recent years, increasing attention has been paid to formulating fast dissolving and/or disintegrating tablets that are swallowed, but also orally disintegrating tablets that are intended to dissolve and/or disintegrate rapidly in the mouth. (1-3) Therefore, the purpose of writing this review on Current Status of Disintegrants was to compile the existing literature on various disintegrants.
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