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Current STR-based techniques in forensic science

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Author(s): Phuvadol Thanakiatkrai

Journal: Maejo International Journal of Science and Technology
ISSN 1905-7873

Volume: 7;
Issue: 01;
Start page: 1;
Date: 2013;
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Keywords: forensic science | DNA | STRs | STR amplification | STR detection

ABSTRACT
DNA analysis in forensic science is mainly based on short tandem repeat (STR) genotyping. The conventional analysis is a three-step process of DNA extraction, amplification and detection. An overview of various techniques that are currently in use and are being actively researched for STR typing is presented. The techniques are separated into STR amplification and detection. New techniques for forensic STR analysis focus on increasing sensitivity, resolution and discrimination power for suboptimal samples. These are achieved by shifting primer-binding sites, using high-fidelity and tolerant polymerases and applying novel methods to STR detection. Examples in which STRs are used in criminal investigations are provided and future research directions are discussed.
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