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Cutaneous Graft-Versus-Host Disease

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Author(s): Emine Çölgeçen | Ayten Ferahbaş

Journal: Turk Dermatoloji Dergisi
ISSN 1307-7635

Volume: 5;
Issue: 04;
Start page: 92;
Date: 2011;
Original page

Keywords: Hematopoietic stem cell transplantation | acute graft versus host disease | chronic graft versus host disease | cutaneous manifestations | patholology | treatment

ABSTRACT
Hematopoietic stem cell transplantation (SCT), which is being used increasingly day by day; is a treatment method for the management of mainly lymphohematopoietic diseases and also immunological and metabolic disorders. Graft versus host disease (GVHD) is a complicated clinical syndrome involving a severe immune reaction mediated by immunologically competent cells, mainly T lymphocytes, resulting in organ dysfunction. It is accepted as the most important cause of mortality and morbidity following SCT. GVHD has also resulted from transfusion of nonirradiated blood products, from maternal-fetal transfusions and following solid organ transplants. In this paper, the clinical manifestations, pathogenesis, histopathology, new classification system and treatment of GVHD is discussed.
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