Academic Journals Database
Disseminating quality controlled scientific knowledge


Author(s): Jithin Jose | P. M. Sunil | Madhavan Nirmal | Soma Susan Varghese

Journal: Oral & Maxillofacial Pathology Journal
ISSN 0976-1225

Volume: 4;
Issue: 2;
Start page: 368;
Date: 2013;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Cytokeratins | Intermediate filaments | cyfra

Cytokeratins are group of intermediate filament proteins and based on thetissue expression, cytokeratins are classified into simple epithelial cytokeratin andstratified epithelial cytokeratins. CK expression pattern in the malignant cells areusually retained from the cell of origin, and therefore CK are being used in tumortyping. Cyfra 21-1 is a soluble fragment of cytokeratin 19 is an acid type cytokeratin,with a molecular weight of 40,000d. The assumption is that Cyfra 21-1 is released intothe bloodstream during cell death, and therefore its level correlates very well with thetumour mass, or more specifically with the necrosis in the tumour, which is a functionof the tumour mass. The aim of this article is to review on cyfra 21-1 and its role as adiagnostic and prognostic marker.
Save time & money - Smart Internet Solutions      Why do you need a reservation system?