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CYP1A1, GSTM1 and GSTT1 Genetic Polymorphism in Egyptian Chronic Myeloid Leukemia Patients

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Author(s): Shereen Mahmoud | Dalia A. Labib | Rania H. Khalifa | Reham E. Abu Khalil | Mohamed A. Marie

Journal: Research Journal of Immunology
ISSN 1994-7909

Volume: 3;
Issue: 1;
Start page: 12;
Date: 2010;
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Keywords: CYP1A1 | GSTT1 | GSTM1 | polymorphisms | CML

ABSTRACT
The genetic polymorphism of xenobiotic metabolizing enzymes: phase I enzymes; cytochrome P450 (CYP1A1) and phase II enzymes; glutathione S-transferase (GSTM1 and GSTT1), were analyzed in 30 chronic myeloid leukemia patients (CML) (19 females, 11 males; age (Mean±SD) 41.7±9.5 years) and 20 age and sex matched healthy controls. The frequency of CYP1A1 alleles and of GSTT1 and GSTM1 homozygous deletions was examined by PCR- RFLP and PCR methods, respectively, using blood samples. The relationship between these genotypes and risk of CML was assessed by means of Odds Ratio (OR) with 95% confidence limits. Present results showed that the frequency of the mutant allele CYP1A1*2A was found to be 3.3% in CML patients and 45% in controls (OR = 0.042, 95% CI: 0.005-0.373; p
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