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Cystone, a Well-known Herbal Formulation Improves Renal Function in Rats with Acute Renal Failure (ARF) Induced by Glycerol Intoxication

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Author(s): Rajesh S | Mohamed Rafiq | Viswanatha Gl | Mohammed Azeemuddin M | Uday Kumar Vk | Patki Ps

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 11;
Issue: 1;
Start page: 15;
Date: 2012;
Original page

Keywords: Acute Renal Failure | Cystone | Glycerol Intoxication | Creatinine Clearance

ABSTRACT
The present study was aimed to evaluate the beneficial effect of Cystone syrup in an experimental animal model of renal failure in rats. Cystone syrup was evaluated against glycerol-induced acute renal failure (ARF) in rats, biochemical parameters, kidney weight and histopathological evaluation was performed to conclude the beneficial effect of Cystone syrup. Administration of single dose of 50% v/v glycerol (8ml/kg.i.m) caused severe renal dysfunction associated with significant increase in markers of renal function such as serum urea (p
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