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Cytogenetic changes in bone marrow and fibroblast cells of BALB/C laboratory mice induced by Mestranol

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Author(s): Teodorović Radislava

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 54;
Issue: 4;
Start page: 263;
Date: 2004;
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Keywords: cytogenetic changes | Mestranol | mouse | fibroblast | bone marrow cells

ABSTRACT
In this work the genotoxic effects provoked by Mestranol, which belongs to the group of chemical rodenticide-chemosterilants, were examined as a function of dose (7,5, 15 and 30 mg/kg w.b./c.c) and of time (10, 20 and 30 days or 3, 5 and 7 days for "in vivo" and "in vitro" conditions respectively). The genotoxic effects were scored on the basis of numerical and structural aberrations in both bone marrow and fibroblast cells from BALB/C laboratory mice in comparison to control groups. Increased doses of the preparation increased numerical aberrations in both bone marrow and fibroblast cells significantly (p
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