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Cytogenetic changes in human lymphocytes induced by alphachlorhydrine

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Author(s): Teodorović Radislava | Stanimirović Z. | Radenković-Damnjanović Brana | Vučinić Marijana | Janković Ljiljana | Đorđević M. | Mirilović M.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 60;
Issue: 5-6;
Start page: 619;
Date: 2010;
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Keywords: Alphachlorhydrine | cytogenetic | genotoxic effects | hyman | lymphocytes

ABSTRACT
This paper deals with the results of the investigation carried out with regard to genotoxic properties of Alphachlorhydrine administered at doses of 7.5, 15 and 30 mg/kg of cell culture-human lymphocytes, during an exposition time of three days, under in vitro conditions. The assessment of the genotoxic effects of the tested chemosterilants was performed on the basis of numerical and structural aberrations in three experimental groups, in addition to one control group for each dose. On the basis of the obtained results it can be conculded that Alphachlorhydrine, administered in the abovementioned doses, induced genotoxic effects on human lymphocyte cells. The number of numeric aberrations increased with a dose increase, and the statistical analysis showed significant differences (p
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