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Cytogenetic study of women with premature ovarian failure

Author(s): Pagni Denise | Melaragno Maria Isabel

Journal: Genetics and Molecular Biology
ISSN 1415-4757

Volume: 21;
Issue: 2;
Start page: 263;
Date: 1998;
Original page

Etiology of premature ovarian failure (POF) is unclear in most patients. Since some cases are related to X-chromosome abnormalities, cytogenetical studies were conducted in patients with POF. Lymphocyte cultures from eleven patients were compared to cultures from age-matched controls. All individuals presented normal karyotypes. Frequencies of aneuploid and structural chromosome aberrations did not differ between the groups. The X chromosome was more frequently involved in aneuploidy and in premature centromere division in both groups.
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