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Cytokeratins In Health And Disease

Author(s): Shailja Chatterjee

Journal: Oral & Maxillofacial Pathology Journal
ISSN 0976-1225

Volume: 3;
Issue: 1;
Start page: 198;
Date: 2012;
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Keywords: Cytokeratin | benign | malignant | odontogenesis | development.

Objective: Cytokeratins are epithelium-specific intermediate filaments. Their altered expression is evident in various benign, hyperplastic and neoplastic lesions. This review provides an in-depth description of cytokeratin expression patterns in odontogenesis; normal development, hyperplastic/benign and malignant lesions or conditions.Materials and methods: Cytokeratin expression can be studied by numerous techniques like immunohistochemistry, immunofluorescence and in situ hybridization.Results: The variable expressivity of cytokeratins is a subject of continuous deliberation and ongoing research. This paper gives an in-depth analysis of cytokeratin expression in a variety of epithelial tissues.Conclusion: Cytokeratins are universal indicators of epithelium specificity. An alteration of expression can be well understood by means of a proper understanding of their normal presence.
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