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Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis

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Author(s): Alinne Silva Andrade Costa | Graciomar Conceição Costa | Dorlene Maria Cardoso de Aquino | Vitor Rosa Ramos de Mendonça | Aldina Barral | Manoel Barral-Netto | Arlene de Jesus Mendes Caldas

Journal: Memórias do Instituto Oswaldo Cruz.
ISSN 0074-0276

Volume: 107;
Issue: 6;
Start page: 735;
Date: 2012;
Original page

Keywords: cytokines | visceral leishmaniasis | clinical forms

ABSTRACT
It is not well established whether cytokine production differs in response to different clinical forms of visceral leishmaniasis (VL). In this work, we performed a cross-sectional study to investigate the plasma levels of cytokines [interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-10 and IL-12] involved in the pathogenesis of VL in 80 subjects from VL endemic areas, including subjects with active VL, subjects with asymptomatic infection, subjects with cured VL and uninfected controls. The patients were recruited by sampling from a referral hospital and by random selection from a population-based cohort study. The results showed significant differences in the plasma concentration of all cytokines between the groups (p < 0.05). Patients with the active disease had higher plasma levels of IL-10, IL-4, INF-γ and TNF-α relative to the other groups and they produced more IL-12 than asymptomatic and cured subjects. Only the IL-2 concentration was higher in the asymptomatic and cured subjects relative to the patients with active disease (p < 0.05). Our results suggest that these cytokines can be used as markers in epidemiological studies conducted in endemic areas to distinguish between different clinical forms of VL. However, their usefulness should be confirmed in investigations conducted in other endemic areas.
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Tango Rapperswil
Tango Rapperswil