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CYTOSOLIC FRACTION OF GLUTHTION LEVEL AFTER ADDITION OF ALUMINUM TO HUMAN BLOOD

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Author(s): Khan Haroon | Khan Muhmmad Farid | Wahab Abdul | Hussain Abid

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 2;
Start page: 550;
Date: 2011;
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Keywords: Aluminium | Glutathione (GSH) | Red Blood Cell (Cytosolic Fraction) | Ellman’s method | 5 | 5-Dithiobis | 2-Nitrobenzoic Acid (DTNB)

ABSTRACT
Aluminium is being used in the medicines in the form of antacids. The Aluminium metal can be leached from our utensils and can harm the body for its side effects, if become available to the systemic circulation. Thus it is interesting to study the Effect of Aluminium on the Glutathione (GSH) in Vivo Conditions. The effect of Aluminium on the chemical status of the Glutathione (GSH) in cytosolic fraction has been studied using U.V Spectrophotometer by using Ellman’s method. The effect of Aluminium on the chemical status of glutathione (GSH) was checked in cytosolic fraction for concentration and time dependent effects. There was found a profound effect on decreasing the concentration of glutathione (GSH) in cytosolic fraction as the concentration is increased and time has passed. The decrease in the glutathione level was concentration and time of interaction dependent, probably due to oxidation of GSH to corresponding disulphide (GSSG).In this paper the effect of Aluminium metal on thiol/GSH level was discussed in vitro, which in principal may present a model of in vivo reaction.
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