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Cytosolic HMGB1 Expression in Human Renal Clear Cell Cancer Indicates Higher Pathological T Classifications and Tumor Grades

Author(s): Takumi Takeuchi | Koichi Sakazume | Akiko Tonooka | Masayoshi Zaitsu | Yuta Takeshima | Koji Mikami | Toshimasa Uekusa

Journal: Urology Journal
ISSN 1735-1308

Volume: 10;
Issue: 3;
Start page: 960;
Date: 2013;
Original page

Keywords: kidney neoplasms | gene expression | HMGB1 protein | genetics | neoplasm invasiveness

Purpose: High mobility group box (HMGB) proteins are nuclear nonhistone chromosomalproteins that bend DNA, bind preferentially to distorted DNA structures, and promote the assemblyof site-specific DNA binding proteins. Recent reports indicate that HMGB1 functionsas a proinflammatory cytokine. Here, we studied expressions of HMGB1 and HMGB2 in humanrenal cancer.Material and Methods: Immunohistological expressions of HMGB1 and HMGB2 were assessedin 39 surgically resected human renal cancer specimens.Results: HMGB1 was expressed in the nucleus in 37 out of 39 (94.9%) renal clear cell cancers,while its expression in the cytosol was noted in 19 cases (48.7%). Cytosolic HMGB1 isexpressed more frequently in cancers beyond the pT1b classification than in those at the pT1aclassification. Higher tumor grades (≥ G2) were also significantly linked with the cytosolicexpression of HMGB1. HMGB2 was expressed in the nucleus in 35 of 39 (89.7%) renal clearcell cancers, while its expression in the cytosol was observed in only 7 case (17.9%). Linkagebetween cytosolic expression of HMGB2 and T classifications was weakly observed, while thatbetween nuclear expression and T classifications was not.Conclusion: HMGB1 expressed in the cytoplasm may be an effective marker indicating higherT classifications and tumor grades.
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