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Cytotoxic Effect of Organotin(IV) Benzylisopropyldithiocarbamate Compounds on Chang Liver Cell and Hepatocarcinoma HepG2 Cell

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Author(s): N. Awang | N.F. Kamaludin | A.R. Ghazali

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 14;
Issue: 15;
Start page: 768;
Date: 2011;
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Keywords: chang liver cells | hepatocarcinoma HepG2 cells | organotin (IV) | Cytotoxicity | dithiocarbamate

ABSTRACT
Cancer is one of the main causes of mortality and morbidity in world. New compounds are currently being synthesized to combat this disease. The organotins are gaining more attention as anti-cancer agents due to their potent cytotoxicity properties. In this study, a series of newly synthesized organotins namely dimethyltin (IV) (compound 1), dibutyltin (IV) (compound 2) and triphenyltin (IV) benzylisopropyldithiocarbamate (compound 3) were assessed for their cytotoxic activities against human Chang liver cells and hepatocarcinoma HepG2 cells. The cytotoxicity of these organotins in both cells upon 24 h treatment was assessed using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Compound 2 and 3 exhibited potent cytotoxic activities towards both cells where the IC50 values were less then 10 M. The IC50 value for compound 2 was 2.5 M in Chang liver cells and 7.0 M in HepG2 cells whereas compound 3 exhibited an IC50 value of 1.5 M in Chang liver cells and 2.5 M in HepG2 cells. Therefore, compound 2 and 3 were more toxic against human Chang liver cells as compared to hepatocarcinoma HepG2 cells. Interestingly, compound 1 did not have any IC50 value in both cells and hence can be classified as non-toxic. In conclusion, organotin (IV) benzylisopropyldithiocarbamate with insertion of dibutyl and triphenyl functional group possess potent cytotoxicity properties. Structural modification of these compounds can be carried out in further studies to produce less or non toxic effects towards normal human cell.

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