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CYTOTOXICITY AND ANTIBACTERIAL ACTIVITY OF ANDROGAPHIS PENICULATA, EUPHORBIA HIRTA AND URGINIA INDICA

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Author(s): Mahmood Ayesha | Khan Md. Ahad Ali | Chowdhury M. Mohi Uddin

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 4;
Start page: 1186;
Date: 2011;
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Keywords: Andrographis paniculata | Euphorbia hirta | Urgenia indica | Antibacterial | Cytotoxic.

ABSTRACT
Based on the traditional uses, petroleum etheric, ethanolic and aqueous extracts of Andrographis paniculata leaves, Euphorbia hirta leaves and Urginea indica bulbs were subjected to cytotoxicity and antibacterial activity test. In brine shrimp lethality test, the LC50 of aqueous extract of Andrographis paniculata leaves was found to be 600 µg/ml and that of ethanolic and aqueous fractions of Euphorbia hirta leaves were 800 and 80 µg/ml respectively. Similarly, the ethanolic and petroleum etheric extracts of Urginea indica bulbs showed significant mortality in the test shrimp and LC50 were found to be 600 and 100 µg/ml respectively. Again, in disc diffusion test aqueous extract of A. paniculata leaves showed significant inhibition against three bacteria, Bacillus megaterium (6 mm), Shigella dysenteriae (9 mm) and Vibrio cholera (9 mm). Similarly, the ethanolic extract of E. hirta significantly inhibited the growth of Bacillus subtilis (6 mm), Bacillus megaterium (7 mm) Shigella dysenteriae (13 mm) and V. cholera (9 mm). However, the aqueous extract of the plant showed no effect on the growth of the test bacteria. And in case of U. indica bulb extracts, ethanolic fraction produced remarkable zone of inhibition against Bacillus subtilis (7 mm), Bacillus megaterium (5 mm), Staphylococcus aureus (12 mm), Salmonella typhi (9 mm) and Vibrio cholera (11 mm). On the other hand petroleum etheric fraction of it produced zone of inhibition only against Bacillus subtilis (7 mm) and Bacillus cereus (9 mm).
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