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Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type

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Author(s): Yongkai WU | Ting XIAO | Min LI | Ying ZHANG | Yanning GAO | Kelin SUN

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 14;
Issue: 11;
Start page: 848;
Date: 2011;
Original page

Keywords: Decorin | Lung neoplasms | Down-regulation

ABSTRACT
Background and objective Decorin is a protein component of the extracellular matrix. It has been proven that decorin plaid an important role in matrix assembly. The protein is also capable of suppressing tumor cell growth. The aim of this study is to examine the protein levels of decorin in tissue samples of non-small cell lung cancer (NSCLC) patients and evaluate its potential clinical value. Methods Decorin protein levels in tumor tissues and corresponding normal tissues from 16 cases of lung squamous cell carcinoma (SCC) were determined by Western blot analysis. Fifty-one NSCLC samples, including both tumor and normal lung tissues, were examined by immunohistochemical (IHC) staining. Results Western blot results showed that decorin protein levels in 75.0% (12/16) of the SCC tumor tissues were lower than those of the corresponding normal lung tissues. IHC results showed that positively stained decorin was detected in only 11.8% of the tumor tissues, significantly lower than that observed in normal alveoli tissues (53.1%, P
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