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DENDRIMERS AND ITS APPLICATION

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Author(s): V Sujitha | Bhattacharyya Sayani | Prakasam Kalyani

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 25;
Date: 2011;
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Keywords: Dendrimers | Interpenetrate | Initiator core | Arborols | Cascade molecule | Divergent methods | Convergent methods | PAMAMs | Poly(propylene imine) dendrimers | Segment-block dendrimers | Layer-block dendrimers | Contrast agents | Delivery of drugs | Industrial processes.

ABSTRACT
A dendrimer can described as a macromolecule characterized by its highly branched 3D structure which provides a high degree of surface functionality and versatility Dendrimers also referred to as the “Polymers of the 21st century.” Dendrimers components, namely (1) an initiator core (2) Interior layers (generations) composed of repeating units, radically attached to the interior core. (3) Exterior (terminal functionality) attached to the outermost interior generations. The properties of dendrimers are dominated by the functional groups on the molecular surface for example a dendrimer can be water soluble when its end group likes a carboxyl group. The major application of dendrimers are: Gene and oligonucleotide delivery, Targeting of anticancer chemotherapy, As anti-infective agent, In vivo diagnostics, Targeted and Controlled release drug delivery, In photodynamic therapy, In industrial processes etc. Recent successes in simplifying and optimizing the synthesis of dendrimers provide a large variety of structures with reduced cost of their production. Also as research progresses, newer applications of dendrimers will emerge and the future should witness an increasing numbers of commercialized dendrimer based drug delivery systems.
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