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Derivative spectrophotometry method for simultaneous estimation of rupatadine and montelukast in their combined dosage form

Author(s): Patel P | Vaghela V | Rathi S | Rajgor N | Bhaskar V

Journal: Journal of Young Pharmacists
ISSN 0975-1483

Volume: 1;
Issue: 4;
Start page: 354;
Date: 2009;
Original page

Keywords: Combination tablet | first-order derivative spectroscopy | montelukast | rupatadine

This study describes the development and validation for the simultaneous estimation of rupatadine and montelukast by the first-order derivative UV spectroscopy method. The quantification was achieved by the first-order derivative spectroscopy method at 273.46 nm and 297.27 nm over the concentration range of 5-25 µg/ml for estimation of rupatadine and montelukast in a combined tablet formulation. Procedure does not require prior separation of components from the sample. Rupatadine and montelukast were determined at 15 µg/ml with a mean recovery of 99.59 + 0.225 and 99.21 + 0.76, respectively. Calibration curves were linear with a correlation coefficient of 0.9994 and 0.9992 for rupatadine and montelukast, respectively. The relative standard deviation was found to be < 2.0%. The present result shows that the proposed method can be successfully used for simultaneous determination of the drug content in marketed formulations.
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